Phloretin Best Antioxidant Anti-Ageing Evens Skin Tone Phloretin opis A flavonoid substance derived from apples and the bark of apple trees. As for topical application to skin, research has shown that it has antioxidant ability, can improve the look of an uneven skin tone, and also serves as a penetration enhancer, which means it can, when properly formulated, help other beneficial ingredients go beyond the superficial layers of skin.